Why might thiobarbiturates be risky for very thin dogs?

Thiobarbiturates are classified as barbiturates and are known for their high lipid solubility. This characteristic means that when these drugs are administered, they tend to distribute into fatty tissues. In very thin dogs, the lack of adequate fat stores can lead to the drug remaining in circulation for an extended period. Without sufficient fat to absorb and sequester the drug, higher plasma concentrations may occur, potentially resulting in prolonged sedation or anesthesia and an increased risk of adverse effects.

In essence, the pharmacokinetics of thiobarbiturates in lean animals necessitate careful consideration during dosing, as the typical distribution and elimination patterns can be significantly altered. This highlights the importance of tailoring anesthetic dosages to the body composition of the animal to mitigate risks.