Why are cats at a higher risk for aspirin overdose compared to other animals?

Cats are at a higher risk for aspirin overdose primarily because they metabolize aspirin very slowly. This slower metabolism means that the drug remains in their system for a longer period, increasing the likelihood of toxic effects if aspirin is administered. The liver in cats has a limited ability to process certain substances, including aspirin, which can lead to a buildup of the drug and result in adverse reactions or toxicity.

In contrast to other animals, such as dogs or humans, who have more efficient enzymatic pathways for metabolizing aspirin, cats lack certain enzymes that would help to break it down effectively. This is why even small doses of aspirin can lead to serious complications in felines. Understanding this pharmacokinetic difference is crucial in veterinary medicine, as it guides dosage recommendations and helps prevent potential overdoses in cats.