Which form(s) of insulin must be resuspended before administration?

The requirement for resuspension before administration pertains specifically to certain forms of insulin. NPH (Neutral Protamine Hagedorn), PZI (Protamine Zinc Insulin), and Lente insulin are all forms of insulin that are cloudy in appearance due to their formulation, which includes added proteins to prolong their action. These insulins need to be gently mixed to ensure that the active ingredients are evenly distributed before injection. This resuspension is crucial for ensuring the correct dosage of insulin is administered, as their effectiveness can be compromised if not mixed properly.

In contrast, regular insulin, which is clear, does not require resuspension, as it is designed to be administered in its solution form without any additional steps. Similarly, both Lispro and Glargine insulins are also clear solutions and do not require resuspension prior to administration. Therefore, knowing which insulins require mixing is important for proper practical application in veterinary pharmacology, especially in managing diabetic patients.