Where does most biotransformation of drugs occur in the body?

Most biotransformation of drugs occurs in the liver due to its unique structure and high concentration of enzymes involved in drug metabolism. The liver contains a wide variety of enzymes, particularly those in the cytochrome P450 family, which play a crucial role in transforming lipophilic drug compounds into more hydrophilic metabolites. This transformation is essential for enhancing the elimination of drugs from the body, allowing for easier excretion through urine and bile.

While other organs such as the kidneys and intestines can also play roles in drug metabolism, the liver is the primary site due to its specialized function in detoxification and metabolism. The pancreas is not directly involved in drug biotransformation, making it less relevant in this context. Understanding this metabolic process is fundamental for veterinary pharmacology, as it impacts drug dosing, efficacy, and safety in animals.