What treatment might be used for pituitary-dependent hyperadrenocorticism in dogs?

Pituitary-dependent hyperadrenocorticism, commonly known as Cushing's disease, is a condition where the pituitary gland overproduces adrenocorticotropic hormone (ACTH), leading to excessive cortisol production by the adrenal glands. The treatment typically focuses on reducing cortisol levels and managing the symptoms of the disease.

Lysodren (mitotane) and Vetoryl (trilostane) are both effective treatments specifically used for managing pituitary-dependent hyperadrenocorticism in dogs. Mitotane works by selectively destroying adrenal cortex tissue, thereby reducing cortisol production. Trilostane, on the other hand, inhibits an enzyme involved in cortisol synthesis, thereby lowering cortisol levels. These medications aim to restore hormonal balance and alleviate the clinical signs associated with the disease.

Other options listed do not directly address the treatment of hyperadrenocorticism. Insulin and ProZinc are primarily used for managing diabetes mellitus, while Vetsulin is another veterinary insulin product. These options do not target cortisol regulation or treat Cushing's disease specifically. Therefore, the choice of Lysodren and Vetoryl is correct, as they are explicitly designed for this particular endocrine disorder.