True or False: Tissue irritation can be caused by counterirritants.

The statement is true because counterirritants are substances used to relieve pain in deeper tissues by creating a mild inflammatory response on the skin. This local irritation can stimulate blood flow and promote healing, but it can also lead to actual tissue irritation or discomfort at the site of application. Counterirritants are often used in veterinary medicine for conditions like musculoskeletal pain, but their purpose of stimulating irritation can sometimes result in adverse effects if not applied correctly or if the tissue is particularly sensitive.

Understanding this mechanism is crucial for identifying potential risks when using counterirritants in treatments. While they serve a therapeutic role, practitioners must be aware that they can indeed cause tissue irritation as a side effect, particularly in cases where the skin is broken, sensitive, or when the product is used excessively.