Is it permissible to use calcium EDTA in anuric patients?

Calcium EDTA is a chelating agent commonly used to treat heavy metal poisoning. In anuric patients—those who are not producing urine—using calcium EDTA is not permissible due to the risk of toxicity. The chelating process requires renal clearance to eliminate the metal complexes formed in the body. In patients with no urine output, there is a significant risk of accumulation of the drug and potential harmful side effects, including kidney damage and systemic toxicity.

Given these considerations, the safest course of action is to avoid administering calcium EDTA to anuric patients entirely. This ensures patient safety and minimizes the risk of complications associated with improper clearance of the drug and its complexed metals.