In which species is fluorouracil contraindicated due to potential side effects?

Fluorouracil is an antineoplastic agent used primarily in the treatment of various cancers. However, it is known to be particularly toxic to cats. When administered to felines, fluorouracil can cause severe toxic reactions, including gastrointestinal distress, neurological symptoms, and ultimately, can be fatal. Cats have a different metabolic pathway for certain drugs compared to other species, which makes them more susceptible to the adverse effects of fluorouracil.

In veterinary practice, it is critical to recognize the species-specific responses to medications, especially when it comes to potent chemotherapeutic agents. The contraindication of fluorouracil in felines is well-documented and is a significant consideration in veterinary pharmacology to ensure the safety and well-being of the animal. Understanding the unique pharmacokinetics and pharmacodynamics in different species helps prevent serious adverse outcomes when treating conditions that require chemotherapy.