Concurrent use of NSAIDs may have what effect on the effectiveness of captopril?

The concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the effectiveness of captopril, an angiotensin-converting enzyme (ACE) inhibitor commonly used to manage hypertension and heart failure. This occurs because NSAIDs can interfere with the function of the kidneys, leading to reduced renal blood flow.

Captopril works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby decreasing blood pressure and improving cardiac output. However, when NSAIDs are used alongside captopril, they can cause sodium retention and reduce the vasodilatory effects of the ACE inhibitor through several mechanisms, including the inhibition of prostaglandin synthesis, which is essential for maintaining renal blood flow and glomerular filtration rate.

Consequently, this interaction can result in diminished antihypertensive effects, making the management of a patient’s condition less effective. Understanding this interaction is crucial for veterinarians in order to make informed decisions regarding medication regimens for their patients.